PokéIsaac active items

Amaze Mulch

Active · 2-room charge · Abono Insólito in Spanish

You knock back nearby enemies and shots, and stun the enemies

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Basement Key

Active · 3-room charge · Llave Sótano in Spanish

Gives you a key

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Beach Glass

Active · 1-room charge · Cristal Marino in Spanish

You fire twelve of your shots all around you, with all their effects

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Bicycle

Active · 2-room charge · Bicicleta in Spanish

Very high speed for 6 seconds

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Boiled Egg

Active · 1-room charge · Huevo Duro in Spanish

You throw a rotten egg that bursts with poison on landing (doesn't hurt you)

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Camping Gear

Active · 4-room charge · Kit de Acampada in Spanish

You see the whole floor map, secret room included, and gain a soul heart

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Clear Bell

Active · 4-room charge · Campana Clara in Spanish

For 6 seconds, hits you take heal you half a heart instead of hurting you

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Duration

6 seconds

Each hit

Heals you half a heart instead of hurting you

Only you

Doesn't heal your teammates

Damp Mulch

Active · 2-room charge · Abono Lento in Spanish

The room's enemies move in slow motion for 6 seconds

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

DNA Splicers

Active · 1-room charge · Punta ADN in Spanish

You swap places with the farthest enemy and leave it stunned

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Target

The farthest enemy (not bosses)

Stunned

1.5 seconds

Enigma Stone

Active · 2-room charge · Misticristal in Spanish

Takes you to a random room on the floor

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Escape Rope

Active · 3-room charge · Cuerda Huida in Spanish

Returns to the starting room

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Explorer Kit

Active · 3-room charge · Kit Explorador in Spanish

Breaks all rocks, crates and barrels in the room

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Festival Ticket

Active · no charge · Festicupón in Spanish

Pocket slot machine: pay 1 PokéDollar and sometimes win a pickup (no charge)

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Galarica Twig

Active · 1-room charge · Rama de Galanuez in Spanish

You throw a boomerang that stuns enemies and brings back whatever it touches on the floor

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Heavy-Duty Boots

Active · 2-room charge · Botas Gruesas in Spanish

You dash where you're moving without getting hurt, hitting everything you pass through

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Loot Sack

Active · 3-room charge · Saca Botín in Spanish

Six Voltorbs about to explode rain down on the room (they don't hurt you)

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Lure

Active · 3-room charge · Colonia in Spanish

4 to 6 Joltik appear and charge at the room's enemies

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Nomel Berry

Active · 2-room charge · Baya Monli in Spanish

You leave a big acid puddle that burns enemies that step in it

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Old Gateau

Active · 4-room charge · Barrita Plus in Spanish

Heals you one heart

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Poké Ball

Active · 4-room charge

Captures a weak enemy: it will follow you

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Poké Doll

Active · 3-room charge · Muñeco Poké in Spanish

Place a decoy: enemies go after it for a few seconds

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Poké Flute

Active · 3-room charge · Poké Flauta in Spanish

Puts enemies to sleep for 5 seconds; the first hit on a sleeping one deals triple and wakes it

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Duration

5 seconds

Awakening

The first hit deals ×3

Bosses

They don't fall asleep

Poké Radar

Active · 4-room charge

Enemies in the room turn shiny and drop coins

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Pokémon Box Link

Active · 3-room charge · Caja de Pokémon in Spanish

A random companion appears to help you in this room

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

PP Up

Active · 3-room charge · Más PP in Spanish

Duplicates a random pickup on the floor

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Red Flute

Active · 4-room charge · Flauta Roja in Spanish

You recover half a heart for each enemy in the room (up to 3 hearts)

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Surprise Mulch

Active · 4-room charge · Abono Sorpresa in Spanish

Swaps the pickups on the room's floor for random ones

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

White Flute

Active · 2-room charge · Flauta Blanca in Spanish

Pulls everything on the room's floor toward you

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Yellow Nectar

Active · 2-room charge · Néctar Amarillo in Spanish

The room's enemies transform into others from the floor

Found in: Treasure room Shop

Shows up

Tier 1 · from floor 1

Ability Capsule

Active · 6-room charge · Cápsula Habilidad in Spanish

Rerolls the items on the room's pedestals

Found in: Treasure room Shop

Shows up

Tier 2 · from floor 4

Adventure Guide

Active · 4-room charge · Guía de Aventura in Spanish

All enemies in the room take a huge hit

Found in: Treasure room Darkrai deal

Shows up

Tier 2 · from floor 4

Deal price

1 heart container (30 % of the time: 3 soul hearts)

Hit

Your damage ×8 (min. 25)

Card Key

Active · 3-room charge · Llave Magnética in Spanish

You place a Magnemite that shoots enemies until you leave the room

Found in: Treasure room Shop

Shows up

Tier 2 · from floor 4

Catching Pocket

Active · 4-room charge · Bolsillo Captura in Spanish

Your companions are doubled in this room

Found in: Treasure room Celestial Room

Shows up

Tier 2 · from floor 4

Claw Fossil

Active · no charge · Fósil Garra in Spanish

You lose half a heart and deal 40 % more damage in this room (up to twice; no charge)

Found in: Darkrai deal Treasure room

Shows up

Tier 2 · from floor 4

Deal price

1 heart container (30 % of the time: 3 soul hearts)

Damage

×1.4 per use (max. ×2)

Clever Feather

Active · 3-room charge · Pluma Mente in Spanish

Beams of light strike up to five enemies (×3 damage)

Found in: Treasure room Celestial Room

Shows up

Tier 2 · from floor 4

Coin Case

Active · 12-room charge · Monedero in Spanish

Doubles your PokéDollars (up to 99)

Found in: Treasure room Shop

Shows up

Tier 2 · from floor 4

Dynamax Band

Active · 2-room charge · Maximuñequera in Spanish

You fire a huge beam where you're facing that pierces everything

Found in: Treasure room Boss reward

Shows up

Tier 2 · from floor 4

Dynamax Candy

Active · 2-room charge · Caramelo Dinamax in Spanish

You fire a giant shot that deals ×10 damage and pierces everyone

Found in: Treasure room Boss reward

Shows up

Tier 2 · from floor 4

Damage

×10

Energy Root

Active · 6-room charge · Raíz Energía in Spanish

For 6 seconds you're invulnerable, faster and hurt whatever you touch

Found in: Treasure room Boss reward

Shows up

Tier 2 · from floor 4

Duration

6 s

Full Restore

Active · 10-room charge · Restaurar Todo in Spanish

Fully restores your health

Found in: Treasure room Shop

Shows up

Tier 2 · from floor 4

Galactic Key

Active · 4-room charge · Llave Galaxia in Spanish

Takes you to the floor's secret room (or, if there isn't one, the treasure room)

Found in: Treasure room Secret room

Shows up

Tier 2 · from floor 4

Holo Caster

Active · 2-room charge · Holomisor in Spanish

You call in an air strike: a meteor falls on the nearest enemy

Found in: Treasure room Boss reward

Shows up

Tier 2 · from floor 4

Master Ball

Active · 10-room charge

Captures any non-boss enemy, even at full health

Found in: Treasure room Boss reward

Shows up

Tier 2 · from floor 4

Max Mushrooms

Active · 5-room charge · Maxiseta in Spanish

Dynamax! You grow and deal ×1.5 damage for 8 seconds

Found in: Treasure room Shop

Shows up

Tier 2 · from floor 4

Max Repel

Active · 4-room charge · Repelente Máximo in Spanish

A shield protects you from everything for 8 seconds

Found in: Treasure room Shop

Shows up

Tier 2 · from floor 4

Rage Candy Bar

Active · 3-room charge · Caramelo Furia in Spanish

Fire rate ×2 for 6 seconds

Found in: Treasure room Shop

Shows up

Tier 2 · from floor 4

Revival Herb

Active · 6-room charge · Hierba Revivir in Spanish

You gain a soul heart

Found in: Treasure room Celestial Room

Shows up

Tier 2 · from floor 4

Rusted Sword

Active · 2-room charge · Espada Oxidada in Spanish

A slash in front of you that deals ×5 damage and cuts enemy shots

Found in: Treasure room Boss reward

Shows up

Tier 2 · from floor 4

Range

125 px fan in front of you

Damage

×5 your damage (minimum 3 hearts)

Enemy shots

Cuts them

Scanner

Active · 3-room charge · Escáner in Spanish

Scans the enemies in the room: they take 50 % more damage

Found in: Treasure room Boss reward

Shows up

Tier 2 · from floor 4

Stable Mulch

Active · 3-room charge · Abono Fijador in Spanish

The room's enemies turn to stone for 4 seconds (bosses are only slowed)

Found in: Treasure room Shop

Shows up

Tier 2 · from floor 4

Sun Flute

Active · 2-room charge · Flauta Solar in Spanish

Enemy shots in the room switch sides and go after enemies

Found in: Treasure room Boss reward

Shows up

Tier 2 · from floor 4

Shots

Up to 40, now yours

Damage

Your damage (minimum 1 heart)

TM Explosion

Active · 4-room charge · MT Explosión in Spanish

A big explosion around you that doesn't hurt you

Found in: Treasure room Boss reward

Shows up

Tier 2 · from floor 4

Ability Patch

Active · 8-room charge · Parche Habilidad in Spanish

Swaps all your passive items for random ones

Found in: Treasure room Darkrai deal

Shows up

Tier 3 · from floor 9

Deal price

1 heart container (30 % of the time: 3 soul hearts)

Beast Ball

Active · 4-room charge · Ente Ball in Spanish

You launch a wormhole that pulls in and hurts enemies and swallows their shots

Found in: Treasure room Boss reward

Shows up

Tier 3 · from floor 9

Duration

3.3 s

Pull

200 px

Reveal Glass

Active · 4-room charge · Espejo Veraz in Spanish

For 8 seconds, your reflection appears on the other side of the room and shoots with you

Found in: Treasure room Boss reward

Shows up

Tier 3 · from floor 9

Duration

8 seconds

Reflection

On the other side of the room, mirrored

Damage

Same as your shots

Skull Fossil

Active · 4-room charge · Fósil Cráneo in Spanish

You fire four beams in a cross that pierce everything

Found in: Treasure room Darkrai deal

Shows up

Tier 3 · from floor 9

Deal price

1 heart container (30 % of the time: 3 soul hearts)

Wishing Piece

Active · 8-room charge · Pieza Deseo in Spanish

A treasure room item appears

Found in: Treasure room Shop

Shows up

Tier 3 · from floor 9

Eon Ticket

Active · 2-room charge · Ticket Eón in Spanish

Duplicates the items on the room's pedestals. Used up on use

Found in: Boss reward Secret room

Shows up

Tier 4 · from floor 15