PokéIsaac Guide › Items › Secret room

PokéIsaac secret room items

It may be Kecleon's black market, an altar with a treasure, a chest vault, fainted Meowth, slot machines or loose loot. Its treasures are only found here. Revealed by an explosion next to a cracked wall.

Ask the Coach Tell it your Pokémon, your items and your floor: it says what to take, which deal to make and how to beat the boss.

Kecleon: Sells two treasures in secret rooms that appear nowhere else, for 20 PokéDollars each.
Voltorb (bomb): Place it with Q: it explodes after a few seconds, breaks rocks and objects and opens secret rooms.
Slot machine: Spend coins on a spin: sometimes a prize, sometimes it breaks.
Fainted Meowth: Blow it up with a Voltorb for coins, nuggets and sometimes a key.

All 26 items

Big Pearl

Passive · Perla Grande in Spanish

Golden chests open without a key

Found in: Secret room

Blue Card

Passive · Tarjeta Azul in Spanish

Everything in the shop costs half

Found in: Shop Secret room

Shows up: Tier 2 · from floor 4

Comet Shard

Passive · Fragmento Cometa in Spanish

When you enter each fight, a comet falls and hurts all enemies

Found in: Secret room

Enigmatic Card

Passive · Nota Intrigante in Spanish

In each room, one enemy is marked with a skull: if it's the first to fall, it drops a reward

Found in: Treasure room Secret room

Shows up: Tier 1 · from floor 1

Eon Ticket

Active · 2-room charge · Ticket Eón in Spanish

Duplicates the items on the room's pedestals. Used up on use

Found in: Boss reward Secret room

Shows up: Tier 4 · from floor 15

Fluffy Tail

Passive · Cola Skitty in Spanish

You're left with a single heart, but when you fall you come back to life, up to 9 times

Found in: Darkrai deal Secret room

Deal price: 2 heart containers
Lives: 9

Galactic Key

Active · 4-room charge · Llave Galaxia in Spanish

Takes you to the floor's secret room (or, if there isn't one, the treasure room)

Found in: Treasure room Secret room

Shows up: Tier 2 · from floor 4

Lift Key

Passive · Llave Ascensor in Spanish

Fills you up with keys (up to 99)

+99 key

Found in: Boss reward Secret room

Shows up: Tier 4 · from floor 15

Max Revive

Passive · Revivir Máximo in Spanish

If you fall, you come back to life with two hearts (used up)

Found in: Boss reward Secret room Shop

Shows up: Tier 3 · from floor 9

Pearl

Passive · Perla in Spanish

Fills you up with PokéDollars (up to 99)

+99 PokéDollars

Found in: Boss reward Secret room

Shows up: Tier 4 · from floor 15

Power-Up Pocket

Passive · Bolsillo Mejoras in Spanish

Enemies drop twice as much stuff

Found in: Darkrai deal Secret room

Deal price: 1 heart container (30 % of the time: 3 soul hearts)

Pretty Feather

Passive · Pluma Bella in Spanish

The longer you go without taking damage, the faster you move

Found in: Secret room

Purple Nectar

Passive · Néctar Violeta in Spanish

When you enter a room, all enemies are poisoned for a good while

Found in: Treasure room Secret room

Shows up: Tier 2 · from floor 4
Poison: 6 s on entering

Rare Bone

Passive · Hueso Raro in Spanish

Your shots come back to you like a boomerang

Damage +0.4

Found in: Secret room

Relic Band

Passive · Brazalete Antiguo in Spanish

Damage +0.15 for each item you carry (up to +3)

Found in: Secret room

Relic Coin

Passive · Moneda Antigua in Spanish

When you buy something, you sometimes get your money back

Found in: Secret room

Relic Crown

Passive · Corona Antigua in Spanish

You're the king: sometimes, when you enter a room, an enemy surrenders and leaves you a coin

Found in: Secret room

Relic Silver

Passive · Real Plata in Spanish

Enemies you touch turn to gold for a few seconds (they can't move or hurt you); if they die like that, they drop coins

Found in: Treasure room Secret room

Shows up: Tier 2 · from floor 4
Gold: 3 s
Coins: 2 per golden enemy

Relic Statue

Passive · Estatua Antigua in Spanish

If you stand still for a moment, your shots deal double damage

Found in: Secret room

Relic Vase

Passive · Vasija Antigua in Spanish

Saves a coin for each room you clear and gives you double when you go down a floor

Found in: Secret room

Root Fossil

Passive · Fósil Raíz in Spanish

If you stand still without firing for a second, you turn to stone and nothing can hurt you

Found in: Treasure room Secret room

Shows up: Tier 1 · from floor 1
Still: 1 s to turn to stone

Safari Ball

Passive

A Sableye follows you and sometimes brings you a pickup when you clear a room

Found in: Treasure room Secret room

Shows up: Tier 2 · from floor 4
Reward: 30 % per cleared room

Shoal Shell

Passive · Concha Cardumen in Spanish

When you clear a room, a chest sometimes appears

Found in: Secret room

Slowpoke Tail

Passive · Cola Slowpoke in Spanish

Enemies that get close to you (not bosses) move in slow motion

Found in: Secret room

Star Piece

Passive · Trozo Estrella in Spanish

Luck +1 for each secret room you find

Luck +1

Found in: Secret room

Tin of Beans

Passive · Lata de Habas in Spanish

Fills you up with Voltorbs (up to 99)

+99 Voltorb

Found in: Boss reward Secret room

Shows up: Tier 4 · from floor 15

Other item pools: Treasure room items · Boss reward items · Shop items · Darkrai deal items · Celestial Room items · Active items · all 350 items